补肾益气汤辅助治疗肺源性心脏病缓解期患者的效果及安全性评价

古锦田 ¹ , 李 轲 ² , 杨小庆 ¹

(1.唐河县中医院内科七病区,河南 唐河 473400;2.南阳市中医院肾病科,河南 南阳 473000)

摘要 目的:研究补肾益气汤辅助治疗肺源性心脏病缓解期患者的效果及安全性。 方法:选取肺源性心脏病缓解期患者 106 例,依照治疗方案不同分为常规组和研究组,每组各 53 例。 常规组予以常规西医治疗,研究组予以中西医结合治疗。 对比两组疗效、治疗前后肺功能指标[用力肺活量(FVC)、第 1 秒用力呼气容积(FEV 1 )、FEV 1 占预计值百分比(FEV 1 %)]、心功能指标[肺动脉收缩压(PASP)、右心室每搏量(RVSV)、右心室舒张末期容积(RVEDV)、右心室射血分数(RVEF)]、脑纳肽(BNP)浓度、生活质量。 结果:研究组总有效率 96.23%(51/53)高于常规组 75.47%(40/53),两组比较差异有统计学意义(P<0.05);研究组 FEV 1 、FVC、FEV 1 %均高于常规组,两组比较差异有统计学意义(P<0.05);治疗后,研究组 PASP、RVEDV、BNP 浓度低于常规组,RVSV、RVEF 高于常规组,两组比较差异有统计学意义(P<0.05);治疗后,研究组活动受限评分、症状评分、SGRQ 总分、疾病影响评分均低于常规组,两组比较差异有统计学意义(P<0.05)。 结论:补肾益气汤辅助治疗肺源性心脏病缓解期效果显著,能提升患者肺功能、心功能,有助于提高生活质量。

关键词: 补肾益气汤;常规西医治疗;肺源性心脏病缓解期

中图分类号:R541.5 文献标志码:A 文章编号:1008-2409(2022)03-0111-05

Efficacy and safety of Bushen Yiqi decoction in adjuvant treatment of patients with cor pulmonale in remission

GU Jintian 1 , LI Ke 2 , YANG Xiaoqing 1 . (1. Ward VII of Department of Internal Medicine, Hospital of Traditional Chinese Medicine of Tanghe County, Tanghe 473400, China; 2. Dept. of Nephrology, Nanyang Hospital of Traditional Chinese Medicine, Nanyang 473000, China)

Abstract Objective: To study the efficacy and safety of Bushen Yiqi decoction in adjuvant treatment of patients with cor pulmonale in remission. Methods: A total of 106 patients with cor pulmonale in remission were selected and randomized into a conventional group and an experimental group according to different treatment regimens, with 53 cases in each group. The conventional group were treated with conventional Western medicine, while the experimental group were treated with integrated traditional Chinese and Western medicine. Then, the efficacy, the pulmonary function indexes[forced vital capacity(FVC), forced expiratory volume in the first second ( FEV1), percentage of FEV1 to the predicted value (FEV1%)], heart function indexes[pulmonary artery systolic pressure(PASP), right ventricular stroke volume(RVSV), right ventricular end-diastolic volume (RVEDV), right ventricular ejection fraction (RVEF)], brain napeptide(BNP) concentration, and quality of life before and after treatments were compared between the two groups, 75.47%(40/53). Results: The total effective rate of the experimental group was 96.23%(51/53), higher than 75.47%(40/53) of the conventional group, and the difference was statistically significant (P < 0. 05); FEV1, FVC and FEV1% were all higher than those of the conventional group, with statistical differences(P<0.05); after treatment, the concentrations of PASP, RVEDV and BNP in the experimental group were lower than those in the conventional group, and RVSV and RVEF were higher than those in the conventional group, the differences were statistically significant(P<0.05); the activity restriction score, symptom score, SGRQ total score, and disease impact score of the experimental group were lower than those of the conventional group, which were of statistical significances (P<0.05). Conclusion: Bushen Yiqi decoction has a significant effect in the adjuvant treatment of patients with cor pulmonale in the remission, which can improve the lung function and heart function and help improve the quality of life of patients.

Keywords: Bushen Yiqi decoction; conventional western medicine treatment; pulmonary heart disease in remission

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