Apelin-13与阿尔兹海默症的研究进展

高雪 周寿红

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摘要：阿尔茨海默病（AD）是一种进行性神经退行性疾病，它与神经炎症、神经营养因子（BDNF）、氧化应激反应、细胞凋亡等有关。目前，研究发现Apelin/APJ系统具有多种生理作用，且Apelin的表达水平可改变神经元结构。Apelin-13是具有调节作用的神经肽，其通过调节血管反应、抑制细胞凋亡和炎症反应、调节细胞自噬、促进BDNF的生成等途径来保护神经元，从而改善AD的认知缺陷。本文综述Apelin-13在AD中的作用，并阐述Apelin/APJ系统在AD中发挥作用的机制。

关键词：Apelin-13;阿尔兹海默症;神经炎症;神经保护;

Research progress of the relationship between Apelin-13 and Alzheimer′s disease^①

GAO Xue,ZHOU Shouhong^②.(Guilin Medical University,Guilin 541199,China)

Abstract Alzheimer′s disease(AD) is a progressive neurodegenerative disease, which is associated with neuroinflammation, brain derived neurotrophic factor(BDNF), oxidative stress response, apoptosis and soon. Currently, studies have found that Apelin / APJ system have various physiological functions, and the expression level of Apelin could change the structure of neurons. And Apelin-13 is a sort of regulatory neuropeptide, which protects neurons by regulating vascular response, inhibiting apoptosis and inflammatory responses, regulating autophagy, and promoting the formation of BDNF, thus improve AD cognitive deficits. This article reviews the role of Apelin-13 in AD and expounds the mechanism of Apelin /APJ system in AD.

Keywords: Apelin-13; Alzheimer′s disease(AD); neuroinflammation; neuro-protection

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