BAI Xi， BAl Fengxi

( Henan Provincial Chest Hospital,Zhengzhou 450000，China)

AbstractObjective To analyse the effect of Bedaquiline Fumarate combined with 2HVZE/4HVEregimen on sputum negative conversion rate and serum cytokine levels in patients with rifampicin resistantpulmonary tuberculosis. ethods 86 patients with rifampicin resistant pulmonary tuberculosis in ourhospital were divided into Group A and Group B by random number table method, with 43 cases in eachgroup.Group B was treated with 2HVZE/4HVE regimen, and Group A was treated with BedaquilineFumarate combined with 2HVZE/4HVE regimen. The clinical efficacy, cavity closure rate, focusabsorption rate , sputum negative conversion rate , immune function indexes, serum procalcitonin ( PCT)interleukin-6 ( IL-6), tumor necrosis factor-a ('TNF-a ), glutathione S-transferase-T (GST*) levels and incidenee of adverse reactions were compared between the two groups. Results After 6 months of treatment .the clinical total elfective rate, cavity closure rate, focus absorption rate , sputum negative conversion rateand immune function index levels in Group A were higher than those in Group B. And the serum GST*.IL-6, 'T'NF-a, PCT levels in Group A were lower than that in Group B, with a statistically significantdifference ( P<0.05 ). 'There was no significant differenee in the ineidence of adverse reactions between thetwo groups ( P> 0.05 ) . Conclusion 'The adjunctive treatment of Bedaquiline Fumarate is effective in thetreatment of rifampicin resistant pulmonary tuberculosis patients patients, which can alleviate the clinicalsymptoms , regulate immune function and promote the improvement of disease.Keywords: Bedaquiline Fumarate: 2HVZE/4HVE, regimen ; rifampicin resistant pulmonary tuberculosispatients

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