WANG Zhongqun ^② , LU Dingkun

(Dept. of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China)

Abstract Diabetic patients are often associated with a variety of complications, and glucotoxicity caused by hyperglycemia, frequent glucose fluctuations and metabolic memory has increasingly become major factors in the formation of cardiovascular complications, such as cardiomyopathy, heart failure, atherosclerosis, vascular calcification. Based on this, this paper systematically reviews the aspects of glucotoxicity, myocardial metabolism and structural remodeling, glucotoxicity and atherosclerosis, glucotoxicity and vascular calcification and so on combined with the work of our research group in the past decade. It is expected to promote the in-depth study of glucotoxicity, and bring new ideas for the diagnosis, prevention and treatment of diabetic cardiovascular complications.

Keywords: glucotoxicity; myocardial remodeling; atherosclerosis; vascular calcification; diabetes mellitus

DOI:10.19296/ j.cnki.1008-2409.2023-01-002

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