TONG Jie^a,HUANG Yuting^a,LI Liangxian^a,CUI Xiangwen^a,JIN Mingyue^ab

(a.Guangxi Key Laboratory of Brain and Cognitive Neuroscience,b.Guangxi Key Laboratory of Drug Discovery and Optimization, Guilin Medical University, Guilin 541199, China)

Abstractα-synuclein (α-Syn) is a soluble protein that mainly exists in the presynaptic structures of neurons in the central nervous system, participating synaptic vesicle transportation, neurotransmitter release and recycle, and thereby maintaining normal synaptic functions. So far, a lot of evidences have revealed that abnormal aggregation or hyperphosphorylation of α-Syn in the human brain can cause many neurodegenerative diseases, but there are no effective cures for these diseases, even their pathogenesis remains under investigation. To clarify α-Syn physiological is crucial understanding of the pathogenesis of α-Syn related diseases. It will provide new targets for early diagnosis and treatment of the disease.Here,thispaper reviews the latest research progress on the physiological functions and pathological effects of α-Syn.

Keywords: α-synuclein; dyskinesia; Parkinson′s disease; α-synucleinopathy

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