GENG Mingming¹, PAN Chen², YANG Huihui¹

(1. Department of Laboratory, Luoyang Jinghua Hospital, Luoyang 471000, China;2.Department of Laboratory, Luoyang Central Hospital, Luoyang 471000, China)

AbstractObjective To explore the predictive value of combined detection of five coagulation parameters andthromboelastography for the prognosis of acute cerebral infarction ( ACI). ethods 216 ACI patients were selectedthe five coagulation parameters(PT,DD,TT, APTT, FIB)were measured, and the correlation betweenthromboelastography indicators ( K, R, MA, angle α, CI) and the severity of ACI were analyzed. The predictivevalue of combined detection of coagulation and thromboelastography indicators at admission for the prognosis of ACI patients were analyzed. Results At admission, PT, TT, R, and K were compared, with mild>moderate>severe, and the difference was statistically significant ( P<0.05). Comparison of  DD, FIB, angle a, and MA: mild<moderate<severe ( P<0.05). At admission, R and K were negatively correlated with the severity of ACl, DD, FlB, andpositively correlated with PT and TT. Angle a and MA were positively correlated with the severity of ACI, DD, FIBand negatively correlated with PT and TT ( P<0.05 ). The combined detection of thromboelastography indicators R,K, angle α , MA, CI, and coagulation indicators PT, DD, TT, and FIB at admission predicted a poor prognosis for ACI patients with an AUC of 0.946, which was greater than the individual detection of the above indicators. Conclusion The combined detection of thromboelastography and five coagulation parameters has high predictive valuefor the prognosis of ACI patients, and provides a basis for early clinicalevaluation of the severity of ACI.

Keywords ; acute cerebral infarction ; blood coagulation five items; thromboelastography; degree of ilness

DOI:10.19296/i.cnki.1008-2409.2024-04-008

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