丹参多酚酸联合尿激酶溶栓治疗急性缺血性脑卒中的效果

翟明明¹ 陈忠义¹ 周志龙²

1. 信阳市人民医院神经内科2. 河南省人民医院脑血管病科

摘要：目的：探讨注射用丹参多酚酸联合尿激酶溶栓治疗急性缺血性脑卒中（AIS）的效果。方法：选取AIS患者97例，按照随机数字表法分成两组，研究组49例，对照组48例。对照组采用尿激酶溶栓治疗，研究组采用注射用丹参多酚酸联合尿激酶溶栓治疗。分析两组临床疗效、神经功能、相对脑血容量及血液流变学。结果：研究组治疗总有效率94.12%高于对照组的78.43%（P＜0.05）;治疗14 d后，研究组hs-CRP、S100β浓度和美国国立卫生研究院卒中量表（NIHSS）评分以及r-CBV、ηb、ηp、HCT水平均低于对照组（P＜0.05）。结论：丹参多酚酸联合尿激酶溶栓治疗AIS效果显著，能有效改善神经功能及血液流变学，恢复r-CBV含量。

关键词：尿激酶;丹参多酚酸;急性缺血性脑卒中;

Effects of salvianolic acid combined with urokinase thrombolysis on patients with acute ischemicstroke

ZHAI Mingming¹,CHEN Zhongyi¹,ZHOU Zhilong².(1. Dept. of Neurology,Xinyang People′s Hospital,Xinyang 464100;2. Dept. of Cerebrovascular Disease,Henan Provincial People′sHospital,Zhengzhou 450000,China)

Abstract Objective: To investigate the effects of salvianolic acid for injection combined with urokinase thrombolysis on patients with acute ischemic stroke(AIS). Methods: A total of 97 patients with AIS were selected and randomly divided into two groups, with 49 cases in the study group and 48 cases in the control group. The control group were treated with urokinase thrombolysis, while the study group were treated with salvianolic acid for injection combined with urokinase thrombolysis. The clinical efficacy, neurological function, relative cerebral blood volume and blood rheology of patients were compared between the two groups. Results: The total effective rate in the study group was 94.12%, which was higher than 78.43% in the control group(P<0.05); after 14 days of hospitalization, the levels of hs-CRP, S100β and NIHSS scores, and levels of r-CBV,ηb,ηp and HCT as well in the study group were lower than those in the control group(P<0.05). Conclusion: Salvia polyphenolic acid combined with urokinase thrombolysis has asignificant effect on AIS patients, which can effectively improve the neurological functions andhemorheology, and restore the r-CBV level in patients.

Keywords: urokinase; salvianolic acid; acute ischemic stroke(AIS)

PDF下载：点击下载